Análisis de 27 marcadores STR del cromosoma Y en poblaciones de la selva del Perú / Analysis of 27 STR markers of the chromosome Y in the population of the jungle from Peru

Introducción: los marcadores de repeticiones cortas en tándem del cromosoma Y (Y-STR) se ubican en la región no recombinante del cromosoma Y, su herencia es por vía paterna, no son detectables en el ADN femenino. Estas propiedades hacen de los Y-STR una herramienta útil en las investigaciones forenses, como las agresiones sexuales, paternidades y otros delitos violentos; asimismo son útiles en estudios genealógicos y evolutivos. El objetivo de la investigación es ampliar la evidencia científica de la distribución por regiones o país de los haplotipos del cromosoma sexual Y, estudios similares en poblaciones peruanas son escasas debido al número menor de polimorfismos Y-STR de uso frecuente en genética forense y de poblaciones. Material y métodos: en la investigación se analizaron 141 muestras de ADN de la selva del Perú, de las que 104 muestras corresponden a la región de Iquitos (Loreto), 29 muestras son Awajun (Amazonas) y 8 muestras de Tambopata (Madre de Dios). Las muestras fueron procesadas empleando PCR directa con el kit Yfiler™ Plus PCR Amplification para 27 STR, los productos amplificados fueron analizados por electroforesis capilar en el Applied Biosystem™ 3500XL Genetic Analyzer y los datos obtenidos se importaron al software GeneMapper® ID-X v1.5 para generar los perfiles genéticos. Con los resultados obtenidos se realizó el análisis estadístico y la estructura poblacional. Resultados: de las 141 muestras se obtuvieron 106 haplotipos únicos. La diversidad genética para cada marcador Y-STR estuvo entre 0,317 y 0,919. La diversidad haplotípica para la muestra total fue de 0,9906. El estudio registra que los haplotipos Y-STR estudiados presentaron elevado polimorfismo en la población analizada y, por lo tanto, son de gran utilidad en estudios forenses de identificación humana, así como en genética de poblaciones cuando se investigan grupos o individuos de América Latina. (AU)

Y-chromosome-specific short tandem repeat (Y-STR) markers reside on the non-recombinant portion of the Y chromosome, their inheritance is paternal, they are not detectable in female DNA. These properties make Y-STRs a useful tool in forensic investigations such as sexual assault, parenting, and other violent crimes; likewise they are also useful in genealogical and evolutionary studies. The objective of the research is to expand the scientific evidence of the distribution by region or country of the Y sex chromosome haplotypes. Similar studies in Peruvian populations are scarce due to the smaller number of Y-STR polymorphisms frequently used in Forensic and Population Genetics. Material and method: In the investigation, 141 DNA samples from the jungle of Peru were analyzed, of which comprised of 104 samples from Iquitos region (Loreto), 29 samples from Awajun (Amazonas) and 8 samples from Tambopata (Madre de Dios). The samples were processed using direct PCR with the Yfiler™ Plus PCR Amplification kit for 27 STRs, the amplified products were analyzed by capillary electrophoresis on the Applied Biosystem™ 3500XL Genetic Analyzer, and the data obtained was imported into the GeneMapper® ID-X v1.5 software to generate the genetic profiles. With the results obtained, the statistical analysis and the population structure were carried out. Results: Of the 141 samples, 106 unique haplotypes were observed. Gene diversities for each Y-STR marker ranged from 0.317 to 0.919. The haplotype diversity for the total sample was 0.9906. This study supports that the Y-STR haplotypes in this population are highly polymorphic in the analyzed population and, therefore, are very useful in forensic studies of human identification, as well as in population genetics when investigating groups or individuals from Latin America. (AU)

Morfometría de la rama mandibular para la estimación del sexo y edad en una población adulta peruana 2014-2019 / Morphometry of the mandibular ramus for the estimation of sex and age in a peruvian adult population 2014-2019

Objetivo: Evaluar la precisión de la estimación del sexo y edad utilizando la morfometría de la rama mandibular mediante un modelo de regresión lineal múltiple incluyendo el ancho intercondilear, el ancho bigonial, la longitud coronoides, la longitud de la rama mandibular, la longitud del cóndilo, el ancho máximo de la rama mandibular y el ángulo goniaco en una población adulta peruana 2014-2019. Material y métodos: Se utilizaron 174 tomografías computarizadas de 18 a 60 años de edad y se analizaron las variables ancho intercondileo (AI), ancho bigonial (AB), longitud coronoides (LCr), longitud del cóndilo (LC), longitud de la rama mandibular (LRm), ancho máximo de la rama mandibular (AMRm) y ángulo goniaco (AG) del lado derecho de la mandíbula. Resultados: La prueba t de muestras independientes determinó que la mayor diferencia entre el sexo fue en la variable LC con 6.9225 mm, la función discriminante obtuvo una tasa de clasificación correcta del sexo con 82.7% y con el modelo de regresión logística múltiple se obtuvo una sensibilidad en el sexo femenino de 81.2%, una especificidad de 85.7%, el sexo masculino una sensibilidad de 85.7%, una especificidad de 81.2%, en la edad la correlación más alta fue en AG con -0.252. Conclusión: Los coeficientes más potentes fueron en LRm, AI y AB con 0.608, 0.606 y 0.604 respectivamente. La mayor diferencia se encontró en el ancho intercondilar con 9.3 mm entre los sexos, en general el porcentaje de precisión predictiva fue de 83.9% en una población egipcia muy parecido a este estudio. (AU)

Objective: To evaluate the precision of the estimation of sex and age using the morphometry of the mandibular ramus through a multiple linear regression model including the intercondylar width, the bigonial width, the coronoid length, the length of the mandibular ramus, the length of the condyle, the maximum width of the mandibular ramus and the gonial angle in a Peruvian adult population 2014-2019. Material and methods: 174 computed tomography scans from 18 to 60 years of age were used and the variables intercondylar width (AI), bigonial width (AB), coronoid length (CLr), condyle length (LC), ramus length mandibular ramus (MRm), maximum width of the mandibular ramus (MRAm) and gonial angle (AG) of the right side of the mandible. Results: The independent samples t-test determined that the greatest difference between the sexes was in the LC variable with 6.9225 mm, the discriminant function obtained a correct classification rate of the sex with 82.7% and with the multiple logistic regression model a sensitivity in the female sex of 81.2%, a specificity of 85.7%, the male sex a sensitivity of 85.7%, a specificity of 81.2%, in age the highest correlation was in AG with -0.252. Discussion: The most powerful coefficients were in LRm, AI and AB with 0.608, 0.606 and 0.604 respectively. The greatest difference was found in the intercondylar width with 9.3 mm between the sexes, in general the percentage of predictive accuracy was 83.9% in an Egyptian population very similar to this study. (AU)

Construcción y valoración de la pertenencia a una barra brava de fútbol. Las voces de los exintegrantes / Construction and assessment of membership to a soccer barra brava. The voices of former members

En este trabajo describimos la construcción y valoración de la pertenencia a una barra brava de fútbol desde las voces de un grupo de exintegrantes. Desarrollamos entrevistas semi estructuradas con siete exintegrantes de la barra brava Trinchera Norte (Perú), que asistían a los esta-dios en la década de 1990 y ejercían un rol protagónico en la barra brava. Los participantes nos relatan que construyeron su pertenencia a partir de la interacción con un grupo de pares que compartían el interés por un equipo de fútbol. En este grupo se desarrollaron y definieron comportamientos que asumieron y que destacan en la actualidad. Así, valoran el compañerismo, la resiliencia, el orgullo y la lucha por sus metas e ideales como aprendizajes significativos que continúan aplicando en su vida. (AU)

In this paper, we describe the construction and assessment of membership to a football barra brava from the voices of a group of former members. We developed semi-structured interviews with seven former members of the barra brava Trinchera Norte(Peru), who attended the stadiums in the 1990s and played a leading role in the barra brava. The participants tell us that they built their membership from the interaction with a group of peers who shared an in-terest in a soccer team. In this group, behaviors that they assumed and that stand out today were developed and defined. Thus, they value camaraderie, resilience, pride and the fight for their goals and ideals as significant learning that they continue to apply in their lives. (AU)

Quinoa, potatoes, and llamas fueled emergent social complexity in the Lake Titicaca Basin of the Andes.

The Lake Titicaca basin was one of the major centers for cultural development in the ancient world. This lacustrine environment is unique in the high, dry Andean altiplano, and its aquatic and terrestrial resources are thought to have contributed to the florescence of complex societies in this region. Nevertheless, it remains unclear to what extent local aquatic resources, particularly fish, and the introduced crop, maize, which can be grown in regions along the lakeshores, contributed to facilitating sustained food production and population growth, which underpinned increasing social political complexity starting in the Formative Period (1400 BCE to 500 CE) and culminating with the Tiwanaku state (500 to 1100 CE). Here, we present direct dietary evidence from stable isotope analysis of human skeletal remains spanning over two millennia, together with faunal and floral reference materials, to reconstruct foodways and ecological interactions in southern Lake Titicaca over time. Bulk stable isotope analysis, coupled with compound-specific amino acid stable isotope analysis, allows better discrimination between resources consumed across aquatic and terrestrial environments. Together, this evidence demonstrates that human diets predominantly relied on C3 plants, particularly quinoa and tubers, along with terrestrial animals, notably domestic camelids. Surprisingly, fish were not a significant source of animal protein, but a slight increase in C4 plant consumption verifies the increasing importance of maize in the Middle Horizon. These results underscore the primary role of local terrestrial food resources in securing a nutritious diet that allowed for sustained population growth, even in the face of documented climate and political change across these periods.

Loxoscelismo cutáneo-visceral en una zona rural con desenlace favorable / Viscerocutaneous loxoscelism with a favorable outcome in a rural area

En el Perú los accidentes por mordedura de araña representan un problema de salud colectiva; de estos, el producido por la araña Loxosceles ha sido causa de numerosas muertes sobre todo en la costa. Esta tiende a ocasionar, ya sea una lesión cutánea o un cuadro sistémico, que puede llevar a la muerte del individuo si no es tratado a tiempo. Hasta la fecha no se cuenta con un protocolo de diagnóstico, predicción ni manejo a nivel internacional, por lo que se utilizan opciones terapéuticas sin respaldo de evidencia. Sin embargo, el manejo de soporte oportuno y adecuado es crucial para los cuadros severos. Se presenta el caso inusual de un loxoscelismo cutáneo-visceral o también llamado sistémico ocurrido en una zona rural. Hubo un compromiso renal severo que requirió hemodiálisis con un desenlace favorable a pesar del no uso de suero antiloxoscélico, lo que evidencia la importancia del manejo oportuno con las medidas de soporte adecuadas(AU)

Accidents caused by spider bites are a public health problem in Peru. Of these, those related to Loxosceles spider bites have been the cause of numerous deaths, mainly on the coast. These bites generally result in a cutaneous lesion or systemic involvement, which may threaten the person's life if not treated timely. An international protocol is not yet available for the diagnosis, prediction or management of Loxosceles spider bites. Therefore, therapeutic options are applied which are not supported by evidence. Still, timely and appropriate support management is crucial in severe cases. An unusual case of viscerocutaneous loxoscelism is presented, also known as systemic loxoscelism, which occurred in a rural area. The case was characterized by severe renal involvement requiring hemodialysis, but its outcome was favorable, despite not using antiloxoscelic serum, which shows the importance of timely management based on appropriate support measures(AU)

Evaluaciones psicológicas forenses de abuso sexual en menores: proceso de revelación y cronicidad del evento en la serranía peruana / Forensic psychological evaluations of child sexual abuse: process of disclosure and its chronicity in the peruvian highlands

Objetivo: Analizar la relación que existe entre las características de la víctima, del agresor y del abuso sexual en niñas, niños y adolescentes con el proceso de revelación; así como con la cronicidad del evento en la División del Instituto de Medicina Legal de la Región Junín-Perú. Materiales y métodos: Diseño transversal analítico. Se analizaron todas las evaluaciones psicológicas forenses desarrolladas de enero a diciembre del año 2017, de las cuales se seleccionaron solo aquellas que cumplían con los criterios de selección, quedando un total de 97 casos. Resultados: El 90% de las víctimas fueron de sexo femenino, el 99% de los agresores fueron de sexo masculino, 66,0% de los casos ocurrieron en un ambiente intrafamiliar y el 5% de las víctimas quedó embarazada. La mayor frecuencia de eventos recurrentes fueron al no tener a la madre viviendo en casa (RPa: 1,44; IC95%: 1,34-1,56; p<0,001), vivir fuera de la ciudad (RPa: 1,27; IC95%: 1,11-1,45; p=0,001), el revelar tardíamente el abuso (RPa: 2,94; IC95%: 1,79-4,84; p<0,001), y entre los que revelaron de manera no intencional (RPa: 1,37; IC95%: 1,06-1,78; p=0,001); en cambio, los agresores extrafamiliares fueron menos frecuentes entre los que tuvieron múltiples eventos (RPa: 0,63; IC95%: 0,44-0,91; p=0,014), ajustados por el sexo y la edad. Conclusiones: Los factores asociados al abuso sexual recurrente fueron: relación de la víctima con la madre, lugar de procedencia de la víctima, latencia de revelación, circunstancia de la revelación y tipo de vínculo de la víctima con el agresor. (AU)

Objective: To analyse the relationship between the characteristics of the victim, the aggressor and sexual abuse in children and adolescents with the disclosure process; as well as with the chronicity of the event in the Division of the Institute of Legal Medicine of the Junín region-Perú. Materials and methods: As a general method of research, the scientific method was applied, carrying out a quantitative study, with a cross-sectional design. All forensic psychological evaluations from January to December of 2017 were analysed, of which only those that fulfilled the selection criteria were selected, leaving a total of 97 cases. Results: Of all the victims, 90% were female, 99% of the aggressors were male, 66.0% of cases occurred in a family environment and 5% of victims became pregnant. The highest frequency of recurrent events was when the mother was not living at home (aPR: 1.44; 95%CI: 1.34-1.56; p <.001), living outside the city (aPR: 1, 27; 95%CI: 1.11-1.45; p=.001), late disclosure of abuse (aPR: 2.94; 95%CI: 1.79-4.84; p <.001), and among those who unintentionally revealed the event (aPR: 1.37; 95%CI: 1.06-1.78; p=.001); in contrast, extra-family offenders were less frequent among those with multiple events (aPR: 0.63, 95%CI: 0.44-0.91, p=.014), adjusted for sex and age. Conclusions: The factors associated with recurrent sexual abuse were the victim's relationship with the mother, place of birth of the victim, disclosure latency, circumstance of the disclosure and type of link between victim and aggressor. (AU)

Migration and maize in the Virú Valley: Understanding life histories through multi-tissue carbon, nitrogen, sulfur, and strontium isotope analyses.

OBJECTIVES: Stable isotope analysis can provide crucial insight into the function and development of early state-level societies on the north coast of Peru. MATERIALS AND METHODS: Multi-tissue (bone collagen, tooth enamel, hair, nail, skin, and tendon) stable isotope analyses (carbon, nitrogen, sulfur, and strontium) were conducted for 13 individuals from the lower Virú Valley. RESULTS: Non-seasonal changes in a predominantly C4 -based terrestrial diet, with minimal inputs of marine foods were identified. One individual (Burial 5), however, had a stable isotope signature unlike any previously found on the north coast of Peru, indicating both a large contribution of C3 -terrestrial resources to their diet and an 87 Sr/86 Sr value suggestive of highland residence during childhood. DISCUSSION: This research provides the first strong stable isotope evidence of a highland individual within a coastal burial in northern Peru, new insight into the ritual killing event at Huaca Santa Clara during the late middle horizon and supporting evidence of the importance of C4 terrestrial resources to the developing Virú polity during the early intermediate period.

A Second Chance: Reenactment and Recovery Narratives in a Peruvian Drug Rehabilitation Center.

The following article discusses a collaborative, reenactment film made with the residents of a drug rehabilitation center in Iquitos, Peru. In so doing, it raises questions about narratives of recovery from addiction, and the tensions that emerge between these narratives and the often-ambivalent feelings of the people who tell them. Practices of filmmaking and reenactment generate a collaborative theorization of lived experience-in this case, the multifaceted natures of both addiction and recovery. At the same time, these practices are also attentive to the embodied memories and complex feelings of the film's actors. Further engagement with the filmic materials demonstrates how the film became an active exploration of the ongoing nature of recovery, complicating the therapeutic trajectories of a group of actors struggling to reconcile ambivalent feelings as they attempt to craft new narratives of self.

Metabolomic approach of the antiprotozoal activity of medicinal Piper species used in Peruvian Amazon.

ETHNOPHARMACOLOGICAL RELEVANCE: In the Peruvian Amazon as in the tropical countries of South America, the use of medicinal Piper species (cordoncillos) is common practice, particularly against symptoms of infection by protozoal parasites. However, there is few documented information about the practical aspects of their use and few scientific validation. The starting point of this work was a set of interviews of people living in six rural communities from the Peruvian Amazon (Alto Amazonas Province) about their uses of plants from Piper genus: one community of Amerindian native people (Shawi community) and five communities of mestizos. Infections caused by parasitic protozoa take a huge toll on public health in the Amazonian communities, who partly fight it using traditional remedies. Validation of these traditional practices contributes to public health care efficiency and may help to identify new antiprotozoal compounds. AIMS OF STUDY: To record and validate the use of medicinal Piper species by rural people of Alto Amazonas Province (Peru) and annotate active compounds using a correlation study and a data mining approach. MATERIALS AND METHODS: Rural communities were interviewed about traditional medication against parasite infections with medicinal Piper species. Ethnopharmacological surveys were undertaken in five mestizo villages, namely: Nueva Arica, Shucushuyacu, Parinari, Lagunas and Esperanza, and one Shawi community (Balsapuerto village). All communities belong to the Alto Amazonas Province (Loreto region, Peru). Seventeen Piper species were collected according to their traditional use for the treatment of parasitic diseases, 35 extracts (leaves or leaves and stems) were tested in vitro on P. falciparum (3D7 chloroquine-sensitive strain and W2 chloroquine-resistant strain), Leishmania donovani LV9 strain and Trypanosoma brucei gambiense. Assessments were performed on HUVEC cells and RAW 264.7 macrophages. The annotation of active compounds was realized by metabolomic analysis and molecular networking approach. RESULTS: Nine extracts were active (IC50 ≤ 10 µg/mL) on 3D7 P. falciparum and only one on W2 P. falciparum, six on L. donovani (axenic and intramacrophagic amastigotes) and seven on Trypanosoma brucei gambiense. Only one extract was active on all three parasites (P. lineatum). After metabolomic analyses and annotation of compounds active on Leishmania, P. strigosum and P. pseudoarboreum were considered as potential sources of leishmanicidal compounds. CONCLUSIONS: This ethnopharmacological study and the associated in vitro bioassays corroborated the relevance of use of Piper species in the Amazonian traditional medicine, especially in Peru. A series of Piper species with few previously available phytochemical data have good antiprotozoal activity and could be a starting point for subsequent promising work. Metabolomic approach appears to be a smart, quick but still limited methodology to identify compounds with high probability of biological activity.

Revelations of ancient head shape: Cranial modification in the Cuzco region of Peru, Early Horizon to Inca Imperial Period.

OBJECTIVES: Cranial vault modification (CVM), the intentional reshaping of the head, indicated group affiliation in prehistoric Andean South America. This study aims to analyze CVM data from the Cuzco region of Peru to illuminate patterns of early migration and settlement along with the later impact of the Inca Empire (AD 1438-1532) on the ethnic landscape. MATERIALS AND METHODS: 419 individuals from 10 archaeological sites spanning over 2300 years were assessed for CVM using morphological analysis. RESULTS: CVM patterns show distinct temporal attributes: the tabular type of modification appeared first and dominated the early sample (900 BC-AD 600), followed by an influx of unmodified crania during the Middle Horizon (AD 600-1000). The annular type appeared later during the Late Intermediate Period (AD 1000-1438). In the subsequent period of Inca imperialism, modification rates were higher at sites in the Cuzco countryside than in Cuzco city sites. DISCUSSION: The study results, combined with archaeological and ethnohistoric data, reveal the sociopolitical transformations that occurred prior to and during the rise of the Inca Empire. The influx of unmodified crania during the Middle Horizon resulted at least partly from Wari occupation, while the appearance of the annular type during the LIP points to migration into the area, possibly from the Lake Titicaca region. In the Inca Imperial Period, Inca individuals at Cuzco city sites refrained from modification as a sign of their ethnic identity, while modification patterns in the Cuzco countryside likely reflect state-coerced resettlement of different ethnic groups.

The character of conflict: A bioarchaeological study of violence in the Nasca highlands of Peru during the Late Intermediate Period (950-1450 C.E.).

OBJECTIVES: This study uses osteological and radiocarbon datasets combined with formal quantitative analyses to test hypotheses concerning the character of conflict in the Nasca highlands during the Late Intermediate Period (LIP, 950-1450 C.E.). We develop and test osteological expectations regarding what patterns should be observed if violence was characterized by intragroup violence, ritual conflict, intermittent raiding, or internecine warfare. MATERIALS AND METHODS: Crania (n = 267) were examined for antemortem and perimortem, overkill, and critical trauma. All age groups and both sexes are represented in the sample. One hundred twenty-four crania were AMS dated, allowing a detailed analysis of diachronic patterns in violence among various demographic groups. RESULTS: Thirty-eight percent (102/267) of crania exhibit some form of cranial trauma, a significant increase from the preceding Middle Horizon era. There are distinct trauma frequencies within the three subphases of the LIP, but Phase III (1300-1450 C.E.) exhibits the highest frequencies of all trauma types. Males exhibit significantly more antemortem trauma than females, but both exhibit similar perimortem trauma rates. DISCUSSION: There was chronic, internecine warfare throughout the Late Intermediate Period with important variations in violence throughout the three temporal phases. Evidence for heterogeneity in violent mortality shows a pattern consistent with social substitutability, whereby any and all members of the Nasca highland population were appropriate targets for lethal and sublethal violence. We argue that by testing hypotheses regarding the targets and types of conflict we are better able to explain the causes and consequences of human conflict.

The genetic structure and adaptation of Andean highlanders and Amazonians are influenced by the interplay between geography and culture.

Western South America was one of the worldwide cradles of civilization. The well-known Inca Empire was the tip of the iceberg of an evolutionary process that started 11,000 to 14,000 years ago. Genetic data from 18 Peruvian populations reveal the following: 1) The between-population homogenization of the central southern Andes and its differentiation with respect to Amazonian populations of similar latitudes do not extend northward. Instead, longitudinal gene flow between the northern coast of Peru, Andes, and Amazonia accompanied cultural and socioeconomic interactions revealed by archeology. This pattern recapitulates the environmental and cultural differentiation between the fertile north, where altitudes are lower, and the arid south, where the Andes are higher, acting as a genetic barrier between the sharply different environments of the Andes and Amazonia. 2) The genetic homogenization between the populations of the arid Andes is not only due to migrations during the Inca Empire or the subsequent colonial period. It started at least during the earlier expansion of the Wari Empire (600 to 1,000 years before present). 3) This demographic history allowed for cases of positive natural selection in the high and arid Andes vs. the low Amazon tropical forest: in the Andes, a putative enhancer in HAND2-AS1 (heart and neural crest derivatives expressed 2 antisense RNA1, a noncoding gene related to cardiovascular function) and rs269868-C/Ser1067 in DUOX2 (dual oxidase 2, related to thyroid function and innate immunity) genes and, in the Amazon, the gene encoding for the CD45 protein, essential for antigen recognition by T and B lymphocytes in viral-host interaction.

Perceived stress and well-being: The role of social support as a protective factor among Peruvian immigrants in Spain / Estrés percibido y bienestar: el papel del apoyo social como factor protector en inmigrantes peruanos en España

BACKGROUND: Migration is a potentially stressful process due to the sociocultural changes and the adaptation processes that go along with it. However, social support can mitigate the impact of stress, ease the adaptation process and contribute to migrants' overall well-being. The aim of this study was to explore to what extent social support buffers the effects of stress and ethnic prejudice on subjective well-being and physical symptoms in a Peruvian immigrant community in Spain. METHOD: One hundred and thirty seven people participated in the study, 67.2% of them women and 32.8% men, with an age range between 19 and 64 years, who responded to self-report instruments through an online survey. The statistical analysis consisted of obtaining a structural equation model (SEM) in order to estimate the direct, indirect and total effects involved in the relationships between the study variables. RESULTS: Social support was shown to have a significant direct effect (beta = .174, p = .017) on the participants' degree of subjective well-being, as well as an indirect effect mediated by both stress and ethnic prejudice (beta = .170, p < .001). No significant direct relationship was found between the degree of social support and the severity of participants' physical symptoms. CONCLUSIONS: The level of social support contributes to subjective well-being and acts as a protective factor against the effects of high levels of stress and ethnic prejudice, thus fostering immigrants' process of adaptation to their new socio-cultural context

ANTECEDENTES: La migración es un proceso potencialmente estresante debido a los cambios socioculturales y de adaptación que supone. No obstante, el apoyo social puede moderar el impacto del estrés, favorecer la adaptación y contribuir con el bienestar de las personas. El objetivo de este estudio fue explorar el papel amortiguador del apoyo social sobre el estrés y el prejuicio étnico en el nivel de bienestar subjetivo y en la severidad de síntomas físicos en inmigrantes peruanos residentes en España. MÉTODO: Participaron 137 personas, 67.2% mujeres y 32.8% varones, con un rango de edad entre 19 y 64 años, quienes respondieron instrumentos de autoinforme a través de una encuesta online. El análisis estadístico consistió en obtener un modelo de ecuaciones estructurales (SEM) para estimar los efectos directos, indirectos y totales en la relación entre las variables de estudio. RESULTADOS: El apoyo social obtuvo un efecto directo significativo (Beta =.174, p=.017) sobre el grado de bienestar subjetivo y también un efecto indirecto mediado por el nivel de estrés y el prejuicio étnico (Beta =.170, p<.001). No se encontró ningún efecto directo significativo entre el grado de apoyo social y la severidad de los síntomas físicos. CONCLUSIONES: El grado de apoyo social contribuye con el bienestar subjetivo y ejerce un papel de protección sobre los niveles de estrés y prejuicio étnico, lo cual favorece la adaptación de los inmigrantes a nuevos contextos socioculturales

Population genetic study of a Peruvian population using human identification STRs.

In this study, allele frequencies were determined in a Peruvian population for application to human identification. A population of 601 unrelated individuals was analyzed (400 individuals with the GlobalFiler Express kit and 201 individuals with the VeriFiler Express kit). The locus with the highest power of discrimination (PD) was SE33 (0.9851, 31 alleles), while the least polymorphic locus was D22S1045 (0.75810, 11 alleles). The PE in a similar fashion ranged from 0.2421 (D22S1045) to 0.7818 (SE33). Under the assumption of independence, the combined PD was > 0.9999999999 while the combined PE = 0.9999999933. When comparing the population studied with different populations of Latin America, the greatest Fst genetic distance was obtained with a Venezuelan population (0.052), and the shortest distance was with a Bolivian and Peruvian population (0.004).

Age at diagnosis and health-related quality of life are associated with fatigue in systemic lupus erythematosus patients: Data from the Almenara Lupus Cohort.

OBJECTIVE: To define the factors associated with fatigue in Mestizo patients with Systemic Lupus Erythematosus (SLE). METHODS: This is a cross-sectional study of SLE patients from a single center cohort. Visits were performed every six months. For these analyses, the first visit between October 2017 and December 2018 was included. Demographic and clinical characteristics as well as treatment were recorded at every visit. Fatigue was ascertained with the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-FT), Health-Related Quality of Life (HRQoL) with the LupusQoL, disease activity with the Systemic Lupus Erythematosus Disease Activity Index -2 K (SLEDAI-2K), and damage with the Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology damage index (SDI). Prednisone use was recorded as current daily dose. Immunosuppressive drugs and antimalarial use were recorded as current, past or never. Univariable and multivariable analyses were performed using linear regression models. For the multivariable analyses, model selection followed a backward elimination procedure. RESULTS: Two hundred and twenty-six patients were evaluated. The mean (SD) age at diagnosis was 35.6 (13.1) years, 211 (93.4%) were female; and disease duration was 11.0 (7.3) years. The mean SLEDAI and SDI were 2.4 (3.5) and 1.3 (1.5), respectively. The mean FACIT-FT was 33.1 (10.8). On the multivariable analysis, age at diagnosis and some domains of HRQoL (physical health, emotional health and fatigue) remained associated. CONCLUSIONS: Age at diagnosis is negatively associated with fatigue whereas HRQoL domains like physical health, emotional health and fatigue are positively associated with fatigue.

Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer Is Associated with Indigenous American Ancestry in Latin American Women.

Women of Latin American origin in the United States are more likely to be diagnosed with advanced breast cancer and have a higher risk of mortality than non-Hispanic White women. Studies in U.S. Latinas and Latin American women have reported a high incidence of HER2 positive (+) tumors; however, the factors contributing to this observation are unknown. Genome-wide genotype data for 1,312 patients from the Peruvian Genetics and Genomics of Breast Cancer Study (PEGEN-BC) were used to estimate genetic ancestry. We tested the association between HER2 status and genetic ancestry using logistic and multinomial logistic regression models. Findings were replicated in 616 samples from Mexico and Colombia. Average Indigenous American (IA) ancestry differed by subtype. In multivariate models, the odds of having an HER2+ tumor increased by a factor of 1.20 with every 10% increase in IA ancestry proportion (95% CI, 1.07-1.35; P = 0.001). The association between HER2 status and IA ancestry was independently replicated in samples from Mexico and Colombia. Results suggest that the high prevalence of HER2+ tumors in Latinas could be due in part to the presence of population-specific genetic variant(s) affecting HER2 expression in breast cancer. SIGNIFICANCE: The positive association between Indigenous American genetic ancestry and HER2+ breast cancer suggests that the high incidence of HER2+ subtypes in Latinas might be due to population and subtype-specific genetic risk variants.

An Evolutionary Approach to Binge Drinking Impression Formation: A Cross-Cultural Comparison Between France and Peru.

Evolutionary medicine proposes studying alcohol use and abuse through the lens of modern evolutionary theory. This study ( https://osf.io/p48 uw/) follows this approach and uses an evolutionary framework to predict how young adults (18-35 years old) form impression of a binge drinker. We predicted that displaying sexual dysfunctions (short-term risk) in a binge drinking video would negatively influence attitudes and expectations of a target when compared to cognitive (short-term risk) or long-term deficits. In the following studies, we use a Zahavian framework to understand and influence impression formation of a male binge drinker among women (intersexual selection) and men (intrasexual competition) participants in a subsequent task. Via a randomized experimental online study in France (N = 177, M = 23.39 [4.91], 43.50% men) and a preregistered conceptual replication study in Peru (N = 176, M = 25.61 [4.76], 53.41% men), women exposed to a binge drinking video-describing sexual impotence after a binge drinking episode-tended to downgrade attractiveness evaluation of the binge drinker. However, male participants were not impacted by the different types of signals displayed in the videos. These results show that evolutionary theory could help us understand impression formation in binge drinking context and call for gender-specific health messages.

Endemic violence in a pre-Hispanic Andean community: A bioarchaeological study of cranial trauma from the Majes Valley, Peru.

OBJECTIVES: This study examines violence-related cranial trauma frequencies and wound characteristics in the pre-Hispanic cemetery of Uraca in the lower Majes Valley, Arequipa, Peru, dating to the pre- and early-Wari periods (200-750 CE). Cranial wounds are compared between status and sex-based subgroups to understand how violence shaped, and was shaped by, these aspects of identity, and to reconstruct the social contexts of violence carried out by and against Uracans. MATERIALS AND METHODS: Presence, location, and characteristics (lethality, penetration, and post-traumatic sequelae) of antemortem and perimortem cranial fractures are documented for 145 crania and compared between subgroups. Cranial wounds are mapped in ArcGIS and the locational distribution of injuries is compared between male and female crania. RESULTS: Middle adult males were disproportionately interred at Uraca, particularly in the elite Sector I. The Uraca mortuary population presents the highest rate of cranial trauma reported for pre-Hispanic Peru: 67% of adults present trauma, and among those, 61.1% present more than one cranial injury. Males exhibit significantly more cranial trauma than females and present a higher mean number of injuries per person. Elite males show the highest mean number of injuries per person, more antemortem injuries, and are the only ones with perimortem cranial trauma, bladed injuries, penetrating injuries, and post-traumatic sequelae. Both sexes were most frequently injured on the anterior of the cranium, while the proportion of posterior injuries was higher for females. DISCUSSION: The rate, intensity, and locational patterns of cranial trauma suggests the community was engaged in raids and/or war with enemy groups, some of which may have increased physical violence between community members. Engaging in violence was likely a prerequisite for burial in the elite sector and was bound up with the generation and maintenance of social status differences linked to male social life.

Better Health-Related Quality of Life in Systemic Lupus Erythematosus Predicted by Low Disease Activity State/Remission: Data From the Peruvian Almenara Lupus Cohort.

OBJECTIVE: To determine if low disease activity state (LDAS)/remission predicts a better health-related quality of life (HRQoL). METHODS: Patients with systemic lupus erythematosus from a single center and having completed at least 2 visits were included. Visits were performed every 6 months. HRQoL was measured with the LupusQoL questionnaire. The definition of remission included a Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) score of 0, prednisone daily dosage of ≤5 mg/day, and immunosuppressive drugs on maintenance dose. LDAS was defined as a SLEDAI-2K score of ≤4, prednisone daily dosage of ≤7.5 mg/day, and immunosuppressive drugs as maintenance therapy. For these analyses, remission and LDAS were combined as one variable. Generalized estimating equations were calculated, using as the outcome 1 of each of the 8 components of the LupusQoL questionnaire in the subsequent visit and the activity state in the previous visit. Multivariable models were adjusted for possible confounders. RESULTS: A total of 243 patients were included. During the follow-up, 590 visits (61.6%) were categorized as LDAS/remission. LDAS/remission predicted a better HRQoL in the components of physical health (B = 4.17 [95% confidence interval (95% CI) 1.20, 7.14]; P = 0.006), pain (B = 6.47 [95% CI 3.18, 9.76]; P < 0.001), planning (B = 4.97 [95% CI 1.43, 8.52]; P = 0.006), burden to others (B = 4.12 [95% CI 0.24, 8.01]; P = 0.037], emotional health (B = 4.50 [95% CI 1.56, 7.44]; P = 0.003), and fatigue (B = 3.25 [95% CI 0.04, 6.47]; P = 0.048). CONCLUSION: Being in LDAS/remission predicts a better HRQoL, especially in the components of physical health, pain, planning, burden to others, emotional health, and fatigue.

Relationships between social stigma, stigma experience and self-stigma and impaired quality of life in schizophrenia across three Latin-American countries.

The relationships between stigma and quality of life in schizophrenia (QoL) have been extensively explored but have mostly focused on self-stigma and self-esteem and have never been explored in Latin-America. The objective of this study was to determine which stigma dimensions were associated with QoL in a sample of community-dwelling SZ subjects of three Latin-American countries. Stabilized outpatients with SZ were recruited in three Mental Health Services in three Latin-American countries: Bolivia (N = 83), Chile (N = 85) and Peru (N = 85). Stigma and Qol-SZ were evaluated by self-administered questionnaires, the Internalized Stigma of Mental Illness scale (ISMI-12) and the SQoL-18. 253 participants were included. In multivariate analyses, QoL has been associated with each stigma dimension (social stigma, stigma experience and self-stigma), independently of age, gender, education level, ethnicity, age at illness onset, illness symptomatology and mental health treatment. More specifically, social stigma was significantly associated with impaired psychological and physical well-being, self-esteem and friendship. Self-stigma was significantly associated with impaired psychological well-being, self-esteem and autonomy. The present results confirm the importance of stigma in QoL of SZ subjects and identify new targets to develop stigma-orientated programs. Most of the previous programs have focused on self-stigma while social stigma has shown to be associated with a wide range of impaired QoL areas. Stigma and QoL may have a bidirectional relationship and targeting some specific QoL areas (like autonomy through self-empowerment approaches) may also improve the effectiveness of these programs to reduce stigma impact on the quality of life of subjects with schizophrenia. Future studies should also explore differences across countries as subjects from Bolivia were more frequently Aymara and reported higher stigma and lower QoL than SZ subjects from other countries.